Discussing peptide administration and the advantages/disadvantages:
The main ways you can get a molecule into your body are:
- Injecting it through the skin, straight into the body
- Applying it to the outside skin topically, or transdermally
- Applying it to the skin on the inside of the mouth, or oromucosally
- Applying it through the rectum and absorbing it that way
- Applying it through the vagina and absorbing it that way
Except for injection, these all use skin surfaces to absorb the molecules. Oral intake and swallowing are the same sort of thing, essentially putting it in your stomach where it is absorbed through the stomach lining into the body.
How to use peptides – Advantages and disadvantages of each method:
Injections are very effective at getting a molecule into your body because they bypass any barriers with a pointy little needle. You inject the molecule straight into your body, where it’s distributed via your blood and lymph system to all the cells of the body. Everything you inject is inside your body, so the bio-availability is effectively 100%: everything you want to get in, you’ve gotten in. The difficulty is that it’s an injection, and depending on the size of the needle it may or may not hurt. If what you are injecting is in a water base, you can use a very thin insulin needle and it’s painless – you don’t feel it at all. But if what you’re injecting requires an oily base because it’s a fat-soluble molecule, you need a larger diameter needle to push that oil through. This can be a little more painful, though not agonizing.
Transdermal application means applying the molecule to the surface of the body, where it can be absorbed. You can mix the molecule into a cream or a gel and apply it to the skin. Applying a substance to different surfaces can have different effects. Depending on the size of the molecule, its fat solubility, and the health of the skin, the molecule may be absorbed through the skin. We use this method with a lot of different drugs. If someone suffers from angina, they can apply nitrates to their skin and have them absorbed into the body. If you need assistance with tobacco withdrawal, you can apply nicotine to the skin and have it absorbed into the body to help with the withdrawal effects. Many hormones are also small and fat-soluble enough molecules that they can be absorbed through the skin. Testosterone, estrogen, and progesterone can all be applied to the skin, as can growth-hormone-secreting peptides. The difficulty with skin absorption, other than the fact that bio-availability depends on the size of the particular molecule, is the variability between individuals. Some people absorb creams better than others, and there’s no way of predicting how well a particular person will absorb a cream. Around 10-20% of people don’t absorb creams particularly well, so it’s not an effective way of getting molecules in for them. It can be helpful for the other 80-90%, but the bio-availability is not going to be 100% like it is with an injection.
You can apply molecules to the skin inside the mouth. The skin of the mouth is a much thinner, more absorbent membrane than the skin on the outer body, which is a thicker, more impermeable barrier. Applying the molecules as a troche, which is a lozenge that dissolves slowly in the mouth, or as a spray under your tongue and holding in your mouth, are effective ways of getting the molecule into the body as long as you don’t swallow it. If you swallow it straight away then you move it out of your mouth and into your gut, where you will have trouble absorbing some peptides.
If you swallow peptides, they enter your stomach and gut. Peptides are small proteins, and your gut and stomach’s job is to break down the proteins you eat into their constituent amino acids, then absorb those amino acids to build the proteins that you need inside your body. There are some proteins and molecules that your body can’t break down, and those are the ones that you can take as oral supplements and swallow. These will be absorbed without being broken down and their functions can be distributed throughout the body. However, many of the peptides we use for growth hormone secretion are broken down by digestion. If you swallow these as a tablet, as an oral spray, or as a troche, they will not become active in your body. That’s why it’s important, if you’re using troches or lozenges, to remember not to swallow the dissolving spray or lozenge; you must keep it in your mouth for as long as you can, without saliva, so it has a chance to be absorbed through the lining of the mouth and function as an intact molecule.
Sterility Is of the Utmost Importance
Injection is the most effective way to administer GH-secreting peptides, with 100% bio-availability. Peptides need a water base, so the injection can use a thin needle and be painless. You just need to be careful to maintain sterility. Keep the needles clean, keep the skin clean, don’t reuse the needles, and keep track of your medications. Peptides have good shelf lives, especially when kept in the fridge, so if you make sure they don’t change color and use sterile techniques, the injections will be safe and effective.
If you are interested in the technique of injecting peptides, we have a video on the website that goes through the details of how to do it safely and effectively. We supply needles and syringes with our peptides for your convenience. We also provide our peptides premixed in order to maintain sterility and a good shelf life. In Australia, it’s illegal to provide peptides as a powder, as this relies on people mixing the substance themselves, and that introduces a risk of contamination into the process.